Across TCGA patient cohorts, IGLV9-49 protein abundance is significantly associated with the RNA expression of many other genes, with 7,023 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGLV9-49-associated genes across cancer lineages are IGLV5-45, METTL8, and IRF4. Each is linked with IGLV9-49 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGLV9-49-to-partner and partner-to-IGLV9-49 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV9-49→partner) and Y-score (partner→IGLV9-49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGLV5-45 →	+1.823	+1.162	<.001	<.001	3	5
HNSC	METTL8 →	-0.393	-0.728	.002	.001	3	4
HNSC	IRF4 →	+1.112	+0.691	<.001	.001	3	4
BRCA	CD28 →	+0.680	+0.853	<.001	.001	3	4
GBM	TMEM273 →	+0.689	+0.775	.001	.007	3	4
HNSC	PNOC →	+0.757	+0.738	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,023 associations by consensus.

Exploration

IGLV9-49 survival (RNA) · tumor vs normal (RNA) · all IGLV9-49 data types