Across TCGA patient cohorts, IGLV9-49 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV9-49-associated genes across cancer lineages are RNU1-68P, MIR6515, and RNVU1-19. Each is linked with IGLV9-49 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV9-49-to-partner and partner-to-IGLV9-49 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV9-49→partner) and Y-score (partner→IGLV9-49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-68P →	+0.171	+4.877	<.001	.003	3	2
UCEC	MIR6515 →	+0.436	+4.335	<.001	.007	3	1
UCEC	RNVU1-19 →	+0.951	+3.692	<.001	.007	3	1
UCEC	IGHV4-4 →	+1.714	+3.690	<.001	.007	3	1
SKCM	CYCSP1 →	+0.179	+4.771	<.001	.006	3	1
SKCM	TNPO3P1 →	+0.057	+4.970	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

IGLV9-49 survival (RNA) · tumor vs normal (RNA) · all IGLV9-49 data types