IGLV7-35

Across TCGA pan-cancer cohorts, IGLV7-35 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated IGLV7-35 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher IGLV7-35 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGLV7-35 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

KICH, BRCA, and SKCM are the cancer types where IGLV7-35 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	II,III,IV	0.070	0.828	<.001	72	view →
BRCA	DFS	Tertile	II,III,IV	0.971	0.928	.005	58	view →
SKCM	DFS	Tertile	II,III,IV	0.892	0.636	<.001	56	view →
THYM	OS	Quartile	All	0.588	0.912	.006	48	view →
CESC	DFS	Tertile	All	0.833	0.702	.019	38	view →
HNSC	OS	Tertile	All	0.838	0.731	.009	32	view →
PAAD	DFS	Median	II,III,IV	0.417	0.215	<.001	28	view →
THCA	OS	Tertile	III,IV	0.796	0.932	.014	27	view →
CHOL	DFS	Tertile	All	0.852	0.310	.021	18	view →
UCEC	DFS	Tertile	All	0.539	0.671	.023	18	view →
KIRC	DFS	Tertile	All	0.737	0.895	.013	12	view →
KIRP	DFS	Tertile	All	0.498	0.808	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

IGLV7-35–KICH (OS)

Open the KICH breakdown →