IGLV7-35

Across TCGA pan-cancer cohorts, IGLV7-35 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGLV7-35’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGLV7-35 RNA is repressed in tumor relative to normal tissue. In most cancer types IGLV7-35 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, BRCA, and LUAD are the cancer types where IGLV7-35 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV7-35 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	−1.166	<.001	10	view →
BRCA	Female	II,III,IV	−0.211	<.001	6	view →
LUAD	All	All	+0.500	<.001	4	view →
STAD	All	IV	−2.023	.024	3	view →
READ	All	All	−0.522	<.001	2	view →
LIHC	Male	All	−0.050	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGLV7-35–COAD

Open the COAD breakdown →