Across TCGA patient cohorts, IGLV6-57 protein abundance is significantly associated with the RNA expression of many other genes, with 10,135 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGLV6-57-associated genes across cancer lineages are IGHV3-30, CPNE5, and IGHG3. Each is linked with IGLV6-57 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGLV6-57-to-partner and partner-to-IGLV6-57 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV6-57→partner) and Y-score (partner→IGLV6-57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IGHV3-30 →	+2.969	+0.843	<.001	<.001	3	7
LUAD	CPNE5 →	+0.870	+0.691	<.001	<.001	3	6
OV	IGHG3 →	+2.609	+1.070	<.001	.001	3	6
OV	IGHV3-21 →	+3.300	+1.247	<.001	<.001	3	6
UCEC	AMPD1 →	+0.591	+1.018	<.001	<.001	3	6
LUAD	FAM30A →	+1.137	+0.692	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,135 associations by consensus.

Exploration

IGLV6-57 survival (RNA) · tumor vs normal (RNA) · all IGLV6-57 data types