Across TCGA patient cohorts, IGLV5-45 protein abundance is significantly associated with the RNA expression of many other genes, with 11,159 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGLV5-45-associated genes across cancer lineages are DIPK2B, IGHV3-72, and LINC00924. Each is linked with IGLV5-45 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGLV5-45-to-partner and partner-to-IGLV5-45 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV5-45→partner) and Y-score (partner→IGLV5-45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DIPK2B →	+0.659	+0.919	<.001	<.001	3	4
BRCA	IGHV3-72 →	+1.982	+1.053	<.001	<.001	3	4
PDAC	LINC00924 →	+0.619	+1.002	<.001	<.001	3	4
LSCC	TMEM97 →	-1.082	-0.795	<.001	.001	3	4
LSCC	PRDM1 →	+0.751	+1.029	<.001	.001	3	4
LSCC	CMAHP →	+0.734	+0.966	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,159 associations by consensus.

Exploration

IGLV5-45 survival (RNA) · tumor vs normal (RNA) · all IGLV5-45 data types