Across TCGA pan-cancer cohorts, IGLV5-45 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated IGLV5-45 data layer compared with 1 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV5-45 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGLV5-45 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and KIRP are the cancer types where IGLV5-45 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.759	0.614	<.001	137	view →
SKCM	DFS	Tertile	All	0.690	0.526	<.001	123	view →
KIRP	DFS	Tertile	II,III,IV	0.493	0.853	.001	61	view →
UCEC	DFS	Quartile	III,IV	0.699	0.116	<.001	54	view →
UVM	DFS	Tertile	All	0.402	0.806	.002	36	view →
LIHC	DFS	Tertile	All	0.617	0.428	<.001	35	view →
LUAD	DFS	Quartile	II,III,IV	0.798	0.415	.003	35	view →
SARC	OS	Median	All	0.891	0.785	.001	34	view →
BRCA	DFS	Quartile	All	0.622	0.462	.004	30	view →
LGG	DFS	Tertile	All	0.654	0.794	.016	21	view →
CHOL	DFS	Median	All	0.700	0.189	.005	18	view →
COAD	DFS	Tertile	III,IV	0.710	0.397	.028	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

Exploration

Same gene, other analysis: IGLV5-45 tumor-vs-normal RNA expression · all IGLV5-45 data types