Across TCGA patient cohorts, IGLV5-45 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. COAD shows the largest number of these associations.

The most reproducible IGLV5-45-associated genes across cancer lineages are RN7SL228P, ERHP2, and MIR6507. Each is linked with IGLV5-45 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV5-45-to-partner and partner-to-IGLV5-45 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV5-45→partner) and Y-score (partner→IGLV5-45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL228P →	+0.422	+6.877	<.001	<.001	3	2
SKCM	ERHP2 →	+0.177	+7.219	<.001	<.001	3	2
BRCA	MIR6507 →	+0.359	+8.055	<.001	.007	3	1
SKCM	CELF2-AS2 →	+0.061	+4.979	<.001	.009	3	1
LUAD	KRTAP20-1 →	+0.228	+7.930	<.001	.008	3	1
COAD	LINC02337 →	+0.145	+5.332	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

IGLV5-45 survival (RNA) · tumor vs normal (RNA) · all IGLV5-45 data types