Across TCGA patient cohorts, IGLV4-60 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV4-60-associated genes across cancer lineages are LDHBP3, MIR588, and MIR6794. Each is linked with IGLV4-60 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV4-60-to-partner and partner-to-IGLV4-60 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV4-60→partner) and Y-score (partner→IGLV4-60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LDHBP3 →	+0.064	+4.641	.001	.006	3	2
DLBC	MIR588 →	+0.502	+4.874	<.001	.008	3	1
BRCA	MIR6794 →	+0.453	+8.471	<.001	.005	3	1
BRCA	RNU6-1108P →	+0.322	+7.731	<.001	.009	3	1
BLCA	PSMB7P1 →	+0.104	+7.640	<.001	.009	3	1
SKCM	RPS7P13 →	+0.099	+5.037	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

IGLV4-60 survival (RNA) · tumor vs normal (RNA) · all IGLV4-60 data types