IGLV3-6

Across TCGA patient cohorts, IGLV3-6 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGLV3-6-associated genes across cancer lineages are SNORD115-33, RNA5SP232, and RNU7-9P. Each is linked with IGLV3-6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV3-6-to-partner and partner-to-IGLV3-6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD115-33 grouped by IGLV3-6-low versus IGLV3-6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV3-6→partner) and Y-score (partner→IGLV3-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SNORD115-33 →	+0.465	+7.924	<.001	.008	3	1
LUSC	RNA5SP232 →	+0.376	+7.924	<.001	.008	3	1
LUSC	RNU7-9P →	+0.568	+7.924	<.001	.008	3	1
LUSC	MIR6724-2 →	+0.694	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SNORD115-33 by IGLV3-6 expression — LUSC

Explore this box plot interactively →