IGLV3-6

Across TCGA pan-cancer cohorts, IGLV3-6 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated IGLV3-6 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV3-6 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV3-6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, ACC, and KIRP are the cancer types where IGLV3-6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.818	0.662	.001	121	view →
ACC	DFS	Tertile	All	0.010	0.624	<.001	99	view →
KIRP	DFS	Tertile	II,III,IV	0.158	0.734	.006	81	view →
KIRC	DFS	Tertile	All	0.392	0.682	<.001	30	view →
BRCA	DFS	Median	All	0.568	0.497	.016	28	view →
LUAD	DFS	Tertile	All	0.733	0.621	.017	20	view →
LUSC	OS	Quartile	II,III,IV	0.652	0.798	.014	19	view →
STAD	OS	Median	IV	0.623	0.216	.003	18	view →
THYM	OS	Tertile	IV	0.294	1.000	.025	18	view →
UCS	DFS	Tertile	III,IV	0.180	0.456	.034	18	view →
TGCT	DFS	Tertile	All	0.903	0.724	.015	16	view →
READ	DFS	Median	IV	0.845	0.361	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

IGLV3-6–HNSC (DFS)

Open the HNSC breakdown →