Across TCGA pan-cancer cohorts, IGLV3-4 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated IGLV3-4 data layer.
The strongest signal is observed in thyroid carcinoma (THCA), where higher IGLV3-4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGLV3-4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.
THCA, UCEC, and BRCA are the cancer types where IGLV3-4 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.