Across TCGA pan-cancer cohorts, IGLV3-4 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGLV3-4’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where IGLV3-4 RNA is repressed in tumor relative to normal tissue. In most cancer types IGLV3-4 is over-expressed in tumor, although a few such as STAD and READ show the opposite, repressed pattern.

STAD, READ, and COAD are the cancer types where IGLV3-4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV3-4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	Male	IV	−0.955	.006	3	view →
READ	All	III,IV	−0.430	.018	2	view →
COAD	All	III,IV	−0.280	.010	2	view →
HNSC	Male	IV	+0.185	.037	2	view →
LUAD	All	All	+0.115	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGLV3-4 RNA expression & survival · all IGLV3-4 data types