IGLV3-29

Across TCGA pan-cancer cohorts, IGLV3-29 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IGLV3-29 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV3-29 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGLV3-29 expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

HNSC, DLBC, and GBM are the cancer types where IGLV3-29 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	0.550	0.327	.002	73	view →
DLBC	DFS	Tertile	III,IV	0.070	0.855	.008	27	view →
GBM	OS	Tertile	All	0.078	0.422	<.001	27	view →
MESO	OS	Median	II,III,IV	0.412	0.214	.012	23	view →
SKCM	DFS	Tertile	All	0.860	0.705	.007	14	view →
UCEC	OS	Tertile	IV	0.638	0.339	.034	12	view →
READ	DFS	Median	IV	0.765	0.376	.009	11	view →
KIRC	DFS	Median	All	0.799	0.919	.019	10	view →
STAD	OS	Median	IV	0.642	0.203	.006	9	view →
LUAD	OS	Median	II,III,IV	0.605	0.739	.026	7	view →
PAAD	DFS	Median	II,III,IV	0.523	0.346	.007	6	view →
CHOL	DFS	Median	All	0.724	0.229	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IGLV3-29–HNSC (OS)

Open the HNSC breakdown →