Across TCGA patient cohorts, IGLV3-27 mutation is significantly associated with the RNA expression of many other genes, with 208 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV3-27-associated genes across cancer lineages are RN7SL794P, RNA5SP473, and SNORD90. Each is linked with IGLV3-27 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV3-27-to-partner and partner-to-IGLV3-27 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV3-27→partner) and Y-score (partner→IGLV3-27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL794P →	+0.336	+2.851	<.001	.001	3	2
UCEC	RNA5SP473 →	+0.734	+2.533	.003	.007	3	2
UCEC	SNORD90 →	+0.481	+2.992	<.001	.001	3	2
UCEC	SNORD62A →	+0.523	+2.800	.003	.001	3	2
SKCM	LINC00608 →	+0.016	+3.870	.008	.002	3	1
SKCM	UQCRC2P1 →	+0.017	+3.301	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 208 associations by consensus.

Exploration

IGLV3-27 survival (RNA) · tumor vs normal (RNA) · all IGLV3-27 data types