IGLV3-26

Across TCGA pan-cancer cohorts, IGLV3-26 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated IGLV3-26 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV3-26 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV3-26 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, STAD, and SKCM are the cancer types where IGLV3-26 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.785	0.324	.002	138	view →
STAD	DFS	Tertile	II,III,IV	0.529	0.669	.020	45	view →
SKCM	OS	Tertile	All	0.923	0.324	.002	33	view →
KIRP	DFS	Tertile	II,III,IV	0.191	0.781	<.001	27	view →
GBM	OS	Tertile	All	0.160	0.414	.025	18	view →
OV	OS	Tertile	All	0.849	0.315	.024	12	view →
UVM	OS	Tertile	All	0.315	0.711	.049	9	view →
MESO	OS	Tertile	III,IV	1.000	0.534	.016	3	view →
BLCA	DFS	Tertile	III,IV	1.000	0.460	.045	3	view →
LUAD	DFS	Tertile	All	0.766	0.651	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

IGLV3-26–HNSC (DFS)

Open the HNSC breakdown →