IGLV3-26

Across TCGA pan-cancer cohorts, IGLV3-26 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of IGLV3-26’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGLV3-26 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGLV3-26 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

LUAD and LUSC are the cancer types where IGLV3-26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV3-26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.066	.005	2	view →
LUSC	Female	All	−0.066	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

IGLV3-26–LUAD

Open the LUAD breakdown →