Across TCGA patient cohorts, IGLV3-25 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV3-25-associated genes across cancer lineages are OR1S2, RNU6-1155P, and LRRTM4-AS1. Each is linked with IGLV3-25 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV3-25-to-partner and partner-to-IGLV3-25 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV3-25→partner) and Y-score (partner→IGLV3-25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	OR1S2 →	+0.082	+4.099	.003	.008	3	1
DLBC	RNU6-1155P →	+0.640	+4.491	<.001	.005	3	1
DLBC	LRRTM4-AS1 →	+0.407	+4.099	<.001	.008	3	1
DLBC	LINC02297 →	+0.056	+4.099	.001	.008	3	1
DLBC	TEX28 →	+0.040	+4.491	<.001	.005	3	1
SKCM	MTND5P17 →	+0.057	+5.454	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

IGLV3-25 survival (RNA) · tumor vs normal (RNA) · all IGLV3-25 data types