IGLV3-24

Across TCGA pan-cancer cohorts, IGLV3-24 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGLV3-24 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV3-24 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGLV3-24 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

HNSC, KICH, and ESCA are the cancer types where IGLV3-24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.790	0.597	<.001	108	view →
KICH	OS	Tertile	All	0.295	0.898	<.001	78	view →
ESCA	OS	Tertile	II,III,IV	0.714	0.472	.012	69	view →
LUAD	DFS	Quartile	All	0.805	0.622	.002	45	view →
ACC	OS	Tertile	All	0.133	0.686	.004	36	view →
THCA	OS	Tertile	IV	0.751	1.000	.014	18	view →
CESC	OS	Tertile	All	0.874	0.770	.043	18	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	18	view →
READ	DFS	Median	IV	0.917	0.383	.002	18	view →
OV	OS	Tertile	All	0.489	0.302	.035	12	view →
KIRC	DFS	Quartile	All	0.773	0.892	.018	10	view →
GBM	OS	Tertile	All	0.166	0.419	.045	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGLV3-24–HNSC (OS)

Open the HNSC breakdown →