IGLV3-24

Across TCGA pan-cancer cohorts, IGLV3-24 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of IGLV3-24’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGLV3-24 RNA is repressed in tumor relative to normal tissue. In most cancer types IGLV3-24 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, LUAD, and KICH are the cancer types where IGLV3-24 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV3-24 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.698	<.001	5	view →
LUAD	All	All	+0.422	<.001	5	view →
KICH	Female	All	−0.368	.023	4	view →
BRCA	Female	II,III,IV	−0.187	.001	4	view →
STAD	Male	All	−0.800	.013	3	view →
READ	All	All	−0.740	.014	3	view →
ESCA	All	II,III,IV	+0.500	.019	2	view →
CHOL	All	II,III,IV	+0.445	<.001	2	view →
HNSC	Female	II,III,IV	+0.312	.042	2	view →
KIRP	All	All	−0.179	.045	1	view →
LIHC	Female	II,III,IV	−0.164	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

IGLV3-24–COAD

Open the COAD breakdown →