IGLV3-17

Across TCGA patient cohorts, IGLV3-17 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,663 significant associations in total. THCA shows the largest number of these associations.

The most reproducible IGLV3-17-associated GO terms across cancer lineages are Complement activation, Antibacterial humoral response, and Complement activation, classical pathway. Each is linked with IGLV3-17 in more than 22 cancer types. Because this analysis shows association rather than direction, both IGLV3-17-to-partner and partner-to-IGLV3-17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Complement activation grouped by IGLV3-17-low versus IGLV3-17-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV3-17→partner) and Y-score (partner→IGLV3-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Complement activation →	+0.155	+0.201	<.001	<.001	3	23
THCA	Antibacterial humoral response →	+0.166	+0.215	<.001	<.001	3	23
THCA	Complement activation, classical pathway →	+0.194	+0.207	<.001	<.001	3	21
THCA	B cell mediated immunity →	+0.110	+0.230	<.001	<.001	3	21
THCA	Immunoglobulin production →	+0.079	+0.212	<.001	<.001	3	21
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.166	+0.204	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,663 associations by consensus.

Complement activation by IGLV3-17 expression — THCA

Explore this box plot interactively →