IGLV3-17

Across TCGA pan-cancer cohorts, IGLV3-17 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated IGLV3-17 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IGLV3-17 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGLV3-17 expression acts as an unfavorable survival marker, although some lineages such as SKCM and STAD show a favorable association.

SKCM, STAD, and DLBC are the cancer types where IGLV3-17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.529	0.298	<.001	66	view →
STAD	DFS	Tertile	II,III,IV	0.755	0.419	.001	54	view →
DLBC	DFS	Tertile	All	0.086	0.912	<.001	51	view →
HNSC	OS	Tertile	All	0.853	0.741	.011	39	view →
MESO	OS	Tertile	All	0.433	0.234	.013	37	view →
KIRP	DFS	Tertile	All	0.472	0.851	.002	36	view →
PCPG	OS	Tertile	All	0.415	0.961	<.001	27	view →
KIRC	DFS	Tertile	All	0.453	0.645	.028	18	view →
THYM	OS	Tertile	III,IV	0.212	1.000	.014	18	view →
SARC	DFS	Tertile	All	0.717	0.492	.028	12	view →
LUAD	DFS	Median	IV	0.817	0.518	.026	6	view →
READ	DFS	Quartile	IV	1.000	0.443	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

IGLV3-17–SKCM (OS)

Open the SKCM breakdown →