IGLV3-15

Across TCGA patient cohorts, IGLV3-15 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,310 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGLV3-15-associated GO terms across cancer lineages are Antigen receptor-mediated signaling pathway, B cell mediated immunity, and Antimicrobial humoral response. Each is linked with IGLV3-15 in more than 19 cancer types. Because this analysis shows association rather than direction, both IGLV3-15-to-partner and partner-to-IGLV3-15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen receptor-mediated signaling pathway grouped by IGLV3-15-low versus IGLV3-15-high in SKCM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV3-15→partner) and Y-score (partner→IGLV3-15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Antigen receptor-mediated signaling pathway →	+0.060	+0.084	<.001	<.001	3	20
THCA	B cell mediated immunity →	+0.104	+0.132	<.001	<.001	3	20
THCA	Antimicrobial humoral response →	+0.111	+0.126	<.001	<.001	3	20
SKCM	Alpha-beta T cell activation →	+0.055	+0.080	<.001	<.001	3	19
SKCM	B cell receptor signaling pathway →	+0.080	+0.087	<.001	<.001	3	19
THCA	Complement activation, classical pathway →	+0.181	+0.121	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,310 associations by consensus.

Antigen receptor-mediated signaling pathway by IGLV3-15 expression — SKCM

Explore this box plot interactively →