IGLV3-15

Across TCGA pan-cancer cohorts, IGLV3-15 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated IGLV3-15 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher IGLV3-15 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGLV3-15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

UCS, HNSC, and KIRP are the cancer types where IGLV3-15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	All	0.104	0.688	<.001	108	view →
HNSC	DFS	Tertile	III,IV	0.806	0.639	.004	81	view →
KIRP	OS	Tertile	All	0.378	0.713	<.001	39	view →
OV	OS	Tertile	II,III,IV	0.201	0.328	.024	36	view →
THCA	OS	Tertile	IV	0.751	1.000	.014	27	view →
COAD	DFS	Tertile	All	0.901	0.753	.016	24	view →
READ	DFS	Tertile	II,III,IV	1.000	0.429	.015	24	view →
DLBC	DFS	Tertile	III,IV	0.070	0.855	.008	18	view →
UCEC	OS	Tertile	IV	0.308	0.748	.009	18	view →
LAML	DFS	Tertile	All	0.163	0.440	.006	18	view →
KIRC	DFS	Tertile	III,IV	0.898	0.719	.019	12	view →
CESC	DFS	Tertile	II,III,IV	0.841	0.401	.038	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

IGLV3-15–UCS (OS)

Open the UCS breakdown →