Across TCGA pan-cancer cohorts, IGLV3-12 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IGLV3-12 data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGLV3-12 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGLV3-12 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where IGLV3-12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.718	1.000	.006	16	view →
HNSC	OS	Tertile	All	0.964	0.176	.038	12	view →
LUAD	OS	Median	All	0.904	1.000	.008	10	view →
GBM	DFS	Median	All	0.838	0.548	.007	8	view →
PDAC	OS	Tertile	All	0.669	0.890	.019	4	view →
LSCC	OS	Median	II,III,IV	0.927	0.802	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: IGLV3-12 tumor-vs-normal RNA expression · all IGLV3-12 data types