Across TCGA patient cohorts, IGLV3-12 protein abundance is significantly associated with the RNA expression of many other genes, with 4,456 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGLV3-12-associated genes across cancer lineages are TRIM4, ADAMTS13, and BTBD9. Each is linked with IGLV3-12 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGLV3-12-to-partner and partner-to-IGLV3-12 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV3-12→partner) and Y-score (partner→IGLV3-12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIM4 →	-0.845	-0.666	.004	.003	3	3
GBM	ADAMTS13 →	-0.569	-0.614	<.001	.002	3	3
LUAD	BTBD9 →	-0.620	-0.831	.003	.002	3	3
LUAD	IGLV3-21 →	+1.541	+0.870	.001	.003	3	3
LUAD	DNAJB6P7 →	-0.531	-0.826	.006	.006	3	3
LUAD	LASP1 →	-0.416	-0.661	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,456 associations by consensus.

Exploration

IGLV3-12 survival (RNA) · tumor vs normal (RNA) · all IGLV3-12 data types