IGLV2-8

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGLV2-8 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,969 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGLV2-8-associated proteins across cancer lineages are MZB1, DOCK2, and SEPTIN1. Each is linked with IGLV2-8 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGLV2-8-to-partner and partner-to-IGLV2-8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGLV2-8 versus MZB1 in OV, with a Pearson correlation of 0.72.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV2-8→partner) and Y-score (partner→IGLV2-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVMZB1 →+1.536+3.406<.001<.001310
OVDOCK2 →+0.629+2.796<.001<.001310
GBMSEPTIN1 →+1.100+1.694<.001<.00139
LSCCIRF4 →+0.912+2.145<.001<.00139
HNSCISG20 →+0.744+2.540<.001<.00139
OVMAP4K1 →+0.686+2.099.002<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 12,969 associations by consensus.

IGLV2-8 vs MZB1 — OV

Per-sample scatter of IGLV2-8 vs MZB1 in OV (Pearson r = 0.72).

Explore this scatter interactively →

Exploration