IGLV2-8

Across TCGA pan-cancer cohorts, IGLV2-8 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGLV2-8 data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV2-8 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV2-8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGLV2-8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.682	0.525	<.001	144	view →
SKCM	OS	Median	All	0.829	0.733	<.001	92	view →
BRCA	DFS	Median	All	0.970	0.927	<.001	91	view →
UCEC	OS	Quartile	III,IV	0.756	0.333	.001	48	view →
LIHC	DFS	Median	All	0.610	0.469	<.001	46	view →
SARC	OS	Median	All	0.901	0.773	<.001	42	view →
UVM	OS	Median	II,III,IV	0.444	0.821	.009	39	view →
PAAD	DFS	Quartile	II,III,IV	0.625	0.298	.001	29	view →
LUAD	DFS	Quartile	III,IV	0.815	0.288	.004	28	view →
COAD	OS	Tertile	III,IV	0.843	0.549	.009	23	view →
LGG	OS	Median	All	0.705	0.912	<.001	15	view →
KIRP	DFS	Median	All	0.795	0.959	.015	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGLV2-8–HNSC (DFS)

Open the HNSC breakdown →