IGLV2-8

Across TCGA patient cohorts, IGLV2-8 protein abundance is significantly associated with the RNA expression of many other genes, with 13,141 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGLV2-8-associated genes across cancer lineages are IGLV3-10, IGHM, and CD79A. Each is linked with IGLV2-8 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGLV2-8-to-partner and partner-to-IGLV2-8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGLV2-8 versus IGLV3-10 in BRCA, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV2-8→partner) and Y-score (partner→IGLV2-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGLV3-10 →	+2.457	+1.010	<.001	<.001	3	7
OV	IGHM →	+2.507	+0.913	<.001	<.001	3	7
UCEC	CD79A →	+1.344	+0.764	<.001	.002	3	6
CCRCC	LILRB5 →	+0.895	+0.793	<.001	<.001	3	6
LSCC	TBC1D27P →	+0.370	+0.667	.001	<.001	3	6
BRCA	IRF4 →	+1.339	+1.034	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,141 associations by consensus.

IGLV2-8 vs IGLV3-10 — BRCA

Explore this scatter interactively →