IGLV2-8

Across TCGA patient cohorts, IGLV2-8 mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV2-8-associated genes across cancer lineages are RNU6-781P, OR6P1, and RNA5SP198. Each is linked with IGLV2-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV2-8-to-partner and partner-to-IGLV2-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-781P grouped by IGLV2-8-low versus IGLV2-8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV2-8→partner) and Y-score (partner→IGLV2-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-781P →	+0.570	+3.463	<.001	.003	3	2
BLCA	OR6P1 →	+0.208	+6.814	<.001	<.001	3	2
SKCM	RNA5SP198 →	+0.236	+5.039	<.001	.003	3	2
BRCA	MIR6074 →	+0.267	+7.731	<.001	.009	3	1
UCEC	MIR135B →	+0.913	+3.233	<.001	.005	3	1
UCEC	RNA5SP260 →	+0.682	+3.458	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

RNU6-781P by IGLV2-8 expression — UCEC

Explore this box plot interactively →