IGLV2-28

Across TCGA patient cohorts, IGLV2-28 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,083 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGLV2-28-associated GO terms across cancer lineages are Antibacterial humoral response, Complement activation, classical pathway, and B cell mediated immunity. Each is linked with IGLV2-28 in more than 30 cancer types. Because this analysis shows association rather than direction, both IGLV2-28-to-partner and partner-to-IGLV2-28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antibacterial humoral response grouped by IGLV2-28-low versus IGLV2-28-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV2-28→partner) and Y-score (partner→IGLV2-28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Antibacterial humoral response →	+0.163	+1.426	<.001	<.001	3	31
THCA	Complement activation, classical pathway →	+0.202	+1.333	<.001	<.001	3	31
ESCA	B cell mediated immunity →	+0.107	+0.727	<.001	<.001	3	30
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.167	+1.305	<.001	<.001	3	30
THCA	Antimicrobial humoral response →	+0.107	+1.385	<.001	<.001	3	29
CHOL	B cell receptor signaling pathway →	+0.099	+1.504	<.001	.007	2	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,083 associations by consensus.

Antibacterial humoral response by IGLV2-28 expression — THCA

Explore this box plot interactively →