IGLV2-28

Across TCGA pan-cancer cohorts, IGLV2-28 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated IGLV2-28 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV2-28 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV2-28 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and UCEC are the cancer types where IGLV2-28 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.783	0.637	<.001	130	view →
BRCA	DFS	Median	All	0.969	0.927	<.001	90	view →
UCEC	DFS	Quartile	III,IV	0.856	0.720	.011	68	view →
LUAD	DFS	Tertile	II,III,IV	0.742	0.455	.001	46	view →
LGG	DFS	Tertile	All	0.473	0.836	<.001	30	view →
SKCM	OS	Median	All	0.526	0.283	<.001	30	view →
GBM	OS	Tertile	All	0.214	0.426	.003	27	view →
READ	DFS	Median	IV	0.845	0.344	<.001	18	view →
KIRC	DFS	Quartile	All	0.440	0.687	.004	17	view →
CESC	DFS	Quartile	All	0.863	0.696	.005	16	view →
STAD	OS	Tertile	IV	0.926	0.295	.049	12	view →
MESO	OS	Median	All	0.727	0.295	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

IGLV2-28–HNSC (DFS)

Open the HNSC breakdown →