Across TCGA patient cohorts, IGLV2-23 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLV2-23-associated genes across cancer lineages are MIR6780B, RPL12P40, and ECM1P1. Each is linked with IGLV2-23 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV2-23-to-partner and partner-to-IGLV2-23 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV2-23→partner) and Y-score (partner→IGLV2-23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6780B →	+0.525	+4.296	.003	.008	3	2
SKCM	RPL12P40 →	+0.104	+4.594	<.001	.008	3	1
UCEC	ECM1P1 →	+0.147	+3.354	.002	.007	3	1
UCEC	RN7SL726P →	+0.213	+3.488	.004	.008	3	1
UCEC	IGKV2-40 →	+0.552	+3.801	<.001	.004	3	1
UCEC	MIR8082 →	+0.497	+3.561	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

Exploration

IGLV2-23 survival (RNA) · tumor vs normal (RNA) · all IGLV2-23 data types