Across TCGA patient cohorts, IGLV11-55 protein abundance is significantly associated with the RNA expression of many other genes, with 62 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGLV11-55-associated genes across cancer lineages are SEPSECS, RAB3IP, and ERCC5. Each is linked with IGLV11-55 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV11-55-to-partner and partner-to-IGLV11-55 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV11-55→partner) and Y-score (partner→IGLV11-55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEPSECS →	-1.375	-1.575	.005	.006	3	1
LSCC	RAB3IP →	-1.428	-1.442	.001	.004	3	1
LSCC	ERCC5 →	-0.974	-1.345	.005	.006	3	1
LSCC	MISP3 →	-0.828	-1.368	<.001	.007	3	1
LSCC	TRPC1 →	-1.390	-1.439	.002	.003	3	1
LSCC	SLC6A1 →	+0.358	+1.353	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Exploration

IGLV11-55 survival (RNA) · tumor vs normal (RNA) · all IGLV11-55 data types