Across TCGA pan-cancer cohorts, IGLV11-55 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGLV11-55’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where IGLV11-55 RNA is repressed in tumor relative to normal tissue. In most cancer types IGLV11-55 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

BRCA, LUAD, and PRAD are the cancer types where IGLV11-55 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV11-55 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	−0.119	.008	6	view →
LUAD	All	All	+0.274	<.001	5	view →
PRAD	All	All	+0.036	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IGLV11-55 RNA expression & survival · all IGLV11-55 data types