Across TCGA patient cohorts, IGLV11-55 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGLV11-55-associated genes across cancer lineages are PUDPP1, SNORD116-29, and SNORD115-45. Each is linked with IGLV11-55 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGLV11-55-to-partner and partner-to-IGLV11-55 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV11-55→partner) and Y-score (partner→IGLV11-55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PUDPP1 →	+0.100	+4.970	<.001	.005	3	2
UCEC	SNORD116-29 →	+0.562	+3.525	.001	.008	3	2
SKCM	SNORD115-45 →	+0.949	+4.771	<.001	.006	3	2
UCEC	LINC02348 →	+0.513	+3.778	.003	.006	3	1
SKCM	TSPY15P →	+0.230	+5.469	<.001	.002	3	1
SKCM	CASP3P1 →	+0.084	+5.080	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Exploration

IGLV11-55 survival (RNA) · tumor vs normal (RNA) · all IGLV11-55 data types