IGLV10-67

Across TCGA pan-cancer cohorts, IGLV10-67 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated IGLV10-67 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher IGLV10-67 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGLV10-67 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRC show a favorable association.

KICH, LUAD, and ESCA are the cancer types where IGLV10-67 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.081	0.904	<.001	90	view →
LUAD	DFS	Tertile	II,III,IV	0.868	0.641	<.001	72	view →
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
THYM	OS	Tertile	All	0.534	0.977	<.001	27	view →
LGG	OS	Tertile	All	0.173	0.799	<.001	27	view →
THCA	DFS	Tertile	III,IV	0.593	0.926	.006	18	view →
KIRP	DFS	Tertile	II,III,IV	0.122	0.626	.032	18	view →
KIRC	DFS	Tertile	III,IV	0.890	0.729	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

IGLV10-67–KICH (DFS)

Open the KICH breakdown →