IGLV10-67

Across TCGA pan-cancer cohorts, IGLV10-67 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGLV10-67’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGLV10-67 RNA is repressed in tumor relative to normal tissue. In most cancer types IGLV10-67 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, LUAD, and READ are the cancer types where IGLV10-67 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV10-67 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.233	<.001	5	view →
LUAD	All	All	+0.065	.006	5	view →
READ	All	All	−0.195	.006	4	view →
LUSC	Female	All	−0.130	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IGLV10-67–COAD

Open the COAD breakdown →