IGLV1-62

Across TCGA pan-cancer cohorts, IGLV1-62 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGLV1-62 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGLV1-62 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGLV1-62 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, BLCA, and CESC are the cancer types where IGLV1-62 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.757	0.644	<.001	150	view →
BLCA	DFS	Tertile	All	0.495	0.209	.008	45	view →
CESC	DFS	Median	III,IV	0.799	0.461	.005	42	view →
ACC	OS	Tertile	All	0.133	0.686	.004	36	view →
KIRP	DFS	Tertile	All	0.591	0.851	.005	27	view →
BRCA	DFS	Quartile	All	0.731	0.472	.002	26	view →
UCEC	OS	Tertile	IV	0.946	0.644	.016	26	view →
READ	DFS	Quartile	II,III,IV	1.000	0.384	.014	25	view →
ESCA	OS	Median	III,IV	0.608	0.321	.012	24	view →
LIHC	OS	Tertile	II,III,IV	0.954	0.540	.008	24	view →
DLBC	DFS	Median	All	0.672	0.934	.006	16	view →
SKCM	OS	Median	All	0.531	0.319	.005	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGLV1-62–HNSC (DFS)

Open the HNSC breakdown →