Across TCGA patient cohorts, IGLV1-50 protein abundance is significantly associated with the RNA expression of many other genes, with 2,935 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGLV1-50-associated genes across cancer lineages are ARHGAP9, GMFG, and PIK3R5. Each is linked with IGLV1-50 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGLV1-50-to-partner and partner-to-IGLV1-50 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLV1-50→partner) and Y-score (partner→IGLV1-50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGAP9 →	+1.625	+2.412	<.001	.003	3	3
BRCA	GMFG →	+1.412	+2.267	<.001	.006	3	3
GBM	PIK3R5 →	+1.222	+0.954	<.001	<.001	3	3
GBM	CD53 →	+1.253	+1.199	.001	<.001	3	3
GBM	FGD2 →	+1.596	+1.058	<.001	<.001	3	3
BRCA	GAB3 →	+1.003	+1.985	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,935 associations by consensus.

Exploration

IGLV1-50 survival (RNA) · tumor vs normal (RNA) · all IGLV1-50 data types