Across TCGA pan-cancer cohorts, IGLV1-50 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGLV1-50’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where IGLV1-50 RNA is repressed in tumor relative to normal tissue. In most cancer types IGLV1-50 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.
COAD, LUAD, and BRCA are the cancer types where IGLV1-50 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGLV1-50 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.