IGLV1-41

Across TCGA pan-cancer cohorts, IGLV1-41 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGLV1-41 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher IGLV1-41 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGLV1-41 expression acts as an unfavorable survival marker.

ESCA and SKCM are the cancer types where IGLV1-41 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.082	0.523	<.001	12	view →
SKCM	DFS	Median	II,III,IV	0.136	0.708	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IGLV1-41–ESCA (DFS)

Open the ESCA breakdown →