IGLON5

Across TCGA patient cohorts, IGLON5 mutation is significantly associated with the RNA expression of many other genes, with 234 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLON5-associated genes across cancer lineages are RNA5SP377, SEPTIN14P24, and RNA5SP319. Each is linked with IGLON5 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGLON5-to-partner and partner-to-IGLON5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP377 grouped by IGLON5-low versus IGLON5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLON5→partner) and Y-score (partner→IGLON5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP377 →	+0.609	+6.102	<.001	.001	3	3
LIHC	SEPTIN14P24 →	+0.201	+5.544	<.001	.004	3	2
UCEC	RNA5SP319 →	+0.526	+2.739	<.001	<.001	3	2
UCEC	RNU6-1140P →	+0.415	+2.370	<.001	.008	3	2
COAD	MTCO2P23 →	+0.214	+4.136	<.001	.008	3	2
COAD	PPP1R9A-AS1 →	+0.146	+3.149	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 234 associations by consensus.

RNA5SP377 by IGLON5 expression — LUSC

Explore this box plot interactively →