IGLL5

Across TCGA patient cohorts, IGLL5 mutation is significantly associated with the RNA expression of many other genes, with 3,175 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGLL5-associated genes across cancer lineages are POLE2, RAD51AP1, and CENPA. Each is linked with IGLL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGLL5-to-partner and partner-to-IGLL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE2 grouped by IGLL5-low versus IGLL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGLL5→partner) and Y-score (partner→IGLL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLE2 →	+0.760	+3.828	<.001	<.001	3	3
DLBC	RAD51AP1 →	+0.785	+3.000	.003	.009	3	3
UCEC	CENPA →	+0.732	+2.923	.003	<.001	3	3
UCEC	SGO1 →	+0.865	+3.949	<.001	<.001	3	3
DLBC	ACTL6A →	+0.699	+3.169	.004	.005	3	3
DLBC	BRCA2 →	+0.627	+3.087	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,175 associations by consensus.

POLE2 by IGLL5 expression — UCEC

Explore this box plot interactively →