Across TCGA patient cohorts, IGKV6D-41 mutation is significantly associated with the RNA expression of many other genes, with 164 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV6D-41-associated genes across cancer lineages are MTND6P14, PPP1R14BP5, and PFN1P9. Each is linked with IGKV6D-41 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV6D-41-to-partner and partner-to-IGKV6D-41 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV6D-41→partner) and Y-score (partner→IGKV6D-41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTND6P14 →	+0.029	+4.186	<.001	.007	3	2
LUSC	PPP1R14BP5 →	+0.198	+2.819	.001	.007	3	2
LUSC	PFN1P9 →	+0.108	+2.380	.006	.007	3	2
SKCM	RPL30P16 →	+0.074	+3.300	<.001	.001	3	2
SKCM	SULT6B1 →	+0.047	+3.120	.007	.002	3	1
SKCM	GLRA1 →	+0.038	+3.805	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 164 associations by consensus.

Exploration

IGKV6D-41 survival (RNA) · tumor vs normal (RNA) · all IGKV6D-41 data types