Across TCGA pan-cancer cohorts, IGKV6-21 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGKV6-21’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IGKV6-21 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IGKV6-21 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, PDAC, and LUAD are the cancer types where IGKV6-21 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV6-21 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−0.978	<.001	8	view →
PDAC	All	II,III,IV	+1.083	<.001	6	view →
LUAD	Male	All	−0.968	<.001	5	view →
LSCC	Male	II,III,IV	−0.333	.031	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: IGKV6-21 RNA expression & survival · all IGKV6-21 data types