Across TCGA patient cohorts, IGKV6-21 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV6-21-associated genes across cancer lineages are BPNT2P, OR8S21P, and CASKP1. Each is linked with IGKV6-21 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV6-21-to-partner and partner-to-IGKV6-21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV6-21→partner) and Y-score (partner→IGKV6-21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	BPNT2P →	+0.072	+5.758	<.001	.003	3	1
UCEC	OR8S21P →	+0.314	+4.484	.005	.009	3	1
SKCM	CASKP1 →	+0.155	+5.224	<.001	.007	3	1
SKCM	RN7SL350P →	+0.181	+5.867	<.001	.003	3	1
SKCM	MTCO3P9 →	+0.049	+5.362	<.001	.005	3	1
SKCM	FABP5P6 →	+0.097	+6.080	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

IGKV6-21 survival (RNA) · tumor vs normal (RNA) · all IGKV6-21 data types