Across TCGA patient cohorts, IGKV4-1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,652 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGKV4-1-associated genes across cancer lineages are IRF4, IGLV3-9, and IGKV1D-8. Each is linked with IGKV4-1 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGKV4-1-to-partner and partner-to-IGKV4-1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV4-1→partner) and Y-score (partner→IGKV4-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IRF4 →	+1.222	+0.849	<.001	<.001	3	8
BRCA	IGLV3-9 →	+1.901	+0.610	<.001	<.001	3	8
HNSC	IGKV1D-8 →	+1.121	+0.422	.004	.006	3	8
BRCA	CD79A →	+1.678	+0.778	<.001	<.001	3	7
UCEC	FCRL5 →	+1.120	+0.688	.001	.006	3	7
UCEC	FCRL3 →	+0.699	+0.656	.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,652 associations by consensus.

Exploration

IGKV4-1 survival (RNA) · tumor vs normal (RNA) · all IGKV4-1 data types