IGKV3OR2-5

Across TCGA patient cohorts, IGKV3OR2-5 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,351 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV3OR2-5-associated GO terms across cancer lineages are B cell mediated immunity, Antibacterial humoral response, and Immunoglobulin production. Each is linked with IGKV3OR2-5 in more than 23 cancer types. Because this analysis shows association rather than direction, both IGKV3OR2-5-to-partner and partner-to-IGKV3OR2-5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGKV3OR2-5-low versus IGKV3OR2-5-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3OR2-5→partner) and Y-score (partner→IGKV3OR2-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.117	+0.633	<.001	<.001	3	24
THCA	Antibacterial humoral response →	+0.182	+0.591	<.001	<.001	3	23
THCA	Immunoglobulin production →	+0.081	+0.628	<.001	<.001	3	23
SKCM	B cell receptor signaling pathway →	+0.082	+0.149	<.001	<.001	3	22
SKCM	Regulation of leukocyte proliferation →	+0.049	+0.144	<.001	<.001	3	22
THCA	T cell selection →	+0.069	+0.555	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,351 associations by consensus.

B cell mediated immunity by IGKV3OR2-5 expression — THCA

Explore this box plot interactively →