IGKV3OR2-5

Across TCGA pan-cancer cohorts, IGKV3OR2-5 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGKV3OR2-5 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV3OR2-5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV3OR2-5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

HNSC, OV, and BLCA are the cancer types where IGKV3OR2-5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.753	0.567	<.001	141	view →
OV	OS	Tertile	III,IV	0.663	0.308	.014	72	view →
BLCA	DFS	Tertile	All	0.629	0.204	<.001	51	view →
UCEC	DFS	Tertile	III,IV	0.760	0.455	.001	50	view →
SKCM	DFS	Tertile	All	0.958	0.711	.005	45	view →
READ	DFS	Median	IV	0.917	0.383	.002	26	view →
COAD	DFS	Quartile	All	0.714	0.486	.019	22	view →
LUAD	DFS	Tertile	All	0.739	0.623	.005	21	view →
LGG	DFS	Tertile	All	0.363	0.743	<.001	21	view →
UCS	OS	Tertile	III,IV	0.196	0.602	.011	18	view →
LAML	DFS	Tertile	All	0.250	0.622	.001	18	view →
KIRC	OS	Tertile	All	0.742	0.813	.018	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGKV3OR2-5–HNSC (DFS)

Open the HNSC breakdown →